Armando Salim Munoz-Abraham, Manuel I. Rodriguez-Davalos, Alessandra Bertacco, Brian Wengerter, John P. Geibel, David C. Mulligan
Current Transplantation Reports
March 2016, Volume 3, Issue 1, pp 93-99
The 3D bioprinting process can be achieved by three different printer modalities based on the current technologies, know as micro-extrusion bioprinting, inkjet bioprinting, or laser bioprintin. The article describes briefly the 3D-bioprinting process.
The use of 3D bioprinting has already resulted in printing of blood vessels and vascular networks, bones, cartilage, ears, tracheal grafts – the three greatest success: replacement the complete skull with a 3D-printed, tailor-made plastic skull without adverse event, succesful transplantation of engineered bladder in humans without any major complications, creating a 3D-printed bionic ear.
About current developments:
- vascular structures: tissue-engineered vascular-graft without aneurismal change or graft rupture
- liver: Organovo demonstrated the feasibility of printing metabolically functional 3D hepatic structures and proving that the tissue was capable of cell-cell interaction, protein production, and enzymatic activity
- kidney: Organovo presented their in vitro model of a multicellular, three-dimensional tissue model of human kidney proximal tubule
Future horizonts and Conclusion: the ultimate aim is the complete ontogenic repliation, but it requires a better understanding of intercellular communication and tissue microenvironments futhermore creating of printing protocols.
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